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Multiscale Control of Nanofiber-Composite Hydrogel for Complex 3D Cell Culture by Extracellular Matrix Composition and Nanofiber Alignment |
In order to manipulate the complex behavior of cells in a 3-dimensional (3D) environment, it is important to provide the microenvironment that can accurately portray the complexity of highly anisotropic tissue structures. However, it is technically challenging to generate a complex microenvironment using conventional biomaterials that are mostly isotropic with limited bioactivity. In this study, the gelatin-hyaluronic acid hydrogel incorporated with aqueous-dispersible, short nanofibers capable of in situ alignment is developed to emulate the native heterogeneous extracellular matrix consisting of fibrous and non-fibrous components. The gelatin nanofibers containing magnetic nanoparticles, |
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2024-05-01 Read more about this article in source |
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This book introduces readers to electrospinning, a nanofabrication technique used to produce nanofibers, and discusses the properties and... 10/30/2026
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in Encyclopedia of Green Materials 10/30/2026
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Large amounts of waste crab shells are generated at seafood processing plants. The main component, chitin, can be mechanically processed into... 10/30/2026
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in Encyclopedia of Green Materials 10/30/2026
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This book addresses the critical need for innovative nanofibers and advanced processing techniques in electrospinning, establishing it as an... 10/23/2026
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A comparative fractographic analysis for the effect of polymeric nanofiber reinforcements on the tensile behavior of multi-layered epoxy nanocomposites
This study presents a comparative investigation into the effects of four different nanofibers—PA66, PStX, PAN, and PVB—on the mechanical performance and failure mechanisms of epoxy adhesive films. These nanofiber‐reinforced adhesive layers were manufactured via a dry‐reinforcement resin film infusion method and tested under uniaxial tensile loading. Mechanical results showed that PA66 and PStX nanofibers improved tensile strength by up to 25%, primarily by mitigating crack initiation at free edges and promoting effective fiber–matrix bonding. In contrast, PAN nanofibers induced micro‐cracks at the fiber–resin interface, amplifying crack coalescence and reducing strength by 25%. 03/01/2025