A Small Chemical Tweak Makes DNA Build Two Very Different Nanostructures in ssalimpour

Salimpour Website |Researchers engineered DNA double-crossover tiles with precisely controlled hydrophobic segments, allowing the balance between DNA base pairing and hydrophobic association to determine the order of nanoscale assembly. Shorter hydrophobic chains favored star-like structures,

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A Small Chemical Tweak Makes DNA Build Two Very Different Nanostructures

A Small Chemical Tweak Makes DNA Build Two Very Different Nanostructures

Researchers engineered DNA double-crossover tiles with precisely controlled hydrophobic segments, allowing the balance between DNA base pairing and hydrophobic association to determine the order of nanoscale assembly. Shorter hydrophobic chains favored star-like structures, while longer chains produced crosslinked spherical nucleic acids with enhanced biological stability and annealing-driven self-sorting.