Nanoparticles Reprogram Tumor-Associated Macrophages Into Pro-Inflammatory M1 States in ssalimpour

Salimpour Website |Solid tumors are not merely collections of malignant cells but complex ecosystems comprising tumor cells, stromal cells, and the extracellular matrix (ECM). The tumor microenvironment (TME) fosters immunosuppression through tumor-associated macrophages (TAMs),

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Nanoparticles Reprogram Tumor-Associated Macrophages Into Pro-Inflammatory M1 States

Nanoparticles Reprogram Tumor-Associated Macrophages Into Pro-Inflammatory M1 States

Solid tumors are not merely collections of malignant cells but complex ecosystems comprising tumor cells, stromal cells, and the extracellular matrix (ECM). The tumor microenvironment (TME) fosters immunosuppression through tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and cancer-associated fibroblasts (CAFs), while physical barriers such as dense ECM and abnormal vasculature hinder drug penetration.