Hybrid Nanoparticles Boost p53 mRNA Delivery in Breast Cancer Models in ssalimpour

Researchers engineered hybrid strontium sulfite nanoparticle-modified lipid nanoparticles to deliver p53 mRNA, producing higher reporter-gene expression, higher p53 transcript levels, and greater apoptosis in breast cancer cells than conventional LNPs. In mice, the p53 mRNA-loaded hybrid carrier slowed 4T1 tumor growth, although the study was small and preclinical, and the clearest biodistribution advantage appeared after PEGylation. 10/21/2026

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PI (Physik Instrumente) L.P., a leading provider of precision motion control and nanopositioning solutions, today announced the A-323, a planar air bearing scanner for semiconductor inspection, metrology and photonics applications that demand high throughput. 10/21/2026

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Scientists have long been interested in cellular nanodiscs, tiny particles made from natural cell membranes that mimic many of the functions of living cells. While previous studies demonstrated the therapeutic potential of ... 10/21/2026

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It looks like a small, transparent patch with a rainbow on its surface—or for those old enough to remember, the back of a CD. The patch is the first of its kind in the world and, when combined with an ordinary smartphone ... 10/20/2026

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Scientists have long explored the idea of using insects as our agents in the field in places where humans won't fit or survive. Imagine a cockroach in an earthquake zone, able to skitter into the rubble to map out exactly ... 10/20/2026

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Researchers developed a high-throughput workflow that combined cryogenic spectroscopy, automated statistical analysis, and scanning transmission electron microscopy to link fabrication conditions and junction microstructure to the strongly coupled two-level system (TLS) density across about 6,000 Al/AlOx/Al Josephson junctions. They found that thicker aluminum electrodes and larger grains were associated with an approximately two-thirds lower detectable TLS density, while the precise microscopic cause remains unresolved. 10/20/2026

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A technology developed at The University of Queensland allowing scientists to observe how disease-related proteins behave inside living neurons will be used to advance early drug discovery for neurodegenerative diseases. ... 10/20/2026

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A research team led by senior researcher Minyoung Lee and principal researcher Sunggyu Park of the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science (KIMS), has developed ... 10/19/2026

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Researchers developed eggshell membrane-supported zinc oxide nanocomposites and found that the thermally synthesized formulation provided the strongest sperm cryoprotection and antimicrobial activity in laboratory tests, including semen from 120 men. In rats, it was associated with changes in reproductive, renal, and tissue measures, but the study did not demonstrate improved fertility through mating or establish a clinical treatment. 10/19/2026

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Researchers developed a sacrificial-template porous silica thin film for electrochemically directed oligonucleotide synthesis that increased the available reaction area while preserving localized electrochemical control. The platform supported parallel synthesis of 121-nucleotide strands and recovery of an encoded 60-byte message, while highlighting remaining challenges in synthesis fidelity, parallelism, and cost. 10/16/2026

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Nanotechnology could help crops withstand drought through nanoparticles, nanobubble irrigation, water-retaining hydrogels, and nanosensors, but challenges remain. 10/08/2026

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High-speed nanoindentation and EBSD techniques are employed to analyze self-annealed electroplated Cu, highlighting spatial variations in mechanical properties. 10/06/2026

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Researchers are exploring whether engineered nanocarriers can improve delivery of drugs, genes, and RNA-based therapies to specific lung cells while reducing unwanted effects elsewhere in the body. 09/29/2026

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Developing stretchable displays integrates quantum dot engineering and novel printing methods, addressing key challenges in performance and durability. 09/25/2026

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Silica aerogel is widely recognized for its exceptionally low thermal conductivity; however, its inherent fragility and high porosity limit direct... 09/17/2026

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NanoLabSizer revolutionizes nanoparticle sizing with SR-DLS, enabling fast, non-destructive measurements directly in closed containers without sample prep. 09/17/2026

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