Programmable Hydrogel-Nanocapsule System Improves Cartilage Repair in Osteoarthritis Models in ssalimpour

Salimpour Website |Researchers developed hydro/nano-bFGF, a two-stage delivery system that combines an enzyme-responsive, cartilage-adhesive hydrogel with bFGF-loaded nanocapsules to improve drug retention, cartilage penetration, and growth factor release near chondrocytes. In human osteoarthritic

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Programmable Hydrogel-Nanocapsule System Improves Cartilage Repair in Osteoarthritis Models

Programmable Hydrogel-Nanocapsule System Improves Cartilage Repair in Osteoarthritis Models

Researchers developed hydro/nano-bFGF, a two-stage delivery system that combines an enzyme-responsive, cartilage-adhesive hydrogel with bFGF-loaded nanocapsules to improve drug retention, cartilage penetration, and growth factor release near chondrocytes. In human osteoarthritic cartilage explants and rodent models, the system improved matrix regeneration, cartilage structure, and joint function, while long-term safety and clinical effectiveness remain to be determined in future studies.