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Multiscale Control of Nanofiber-Composite Hydrogel for Complex 3D Cell Culture by Extracellular Matrix Composition and Nanofiber Alignment |
In order to manipulate the complex behavior of cells in a 3-dimensional (3D) environment, it is important to provide the microenvironment that can accurately portray the complexity of highly anisotropic tissue structures. However, it is technically challenging to generate a complex microenvironment using conventional biomaterials that are mostly isotropic with limited bioactivity. In this study, the gelatin-hyaluronic acid hydrogel incorporated with aqueous-dispersible, short nanofibers capable of in situ alignment is developed to emulate the native heterogeneous extracellular matrix consisting of fibrous and non-fibrous components. The gelatin nanofibers containing magnetic nanoparticles, |
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2024-05-01 Read more about this article in source |
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Design and characterization of anti-microbial novel herbal nanofiber scaffolds for the management of periodontal diseases
Design and evaluation of PCL and gelatin loaded nanofiber containing herbal formulation named Ashvakatriin the treatment of chronic periodontitis.... 11/19/2025
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Preparation and Characterization Evaluation of Urushiol/Polyvinyl Alcohol Nanofiber Membranes
In this study, medical-grade polyvinyl alcohol (PVA) is used as the base material and made into PVA nanofiber membranes via electrospinning.... 10/31/2025
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Cellulose acetate butyrate/cellulose Janus nanofiber membrane for unidirectional moisture conduction
Unidirectional conductive wet fiber materials are employed in membrane materials because of their directional transport capability. In this study, a... 10/29/2025
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Diabetic ulcer is a prevalent complication affecting a large number of individuals globally and presents a significant challenge in healthcare, often... 10/27/2025
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Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
The skin, which is a protective barrier for the human body, can be injured from time to time as a result of disease or trauma. Electrospun nanofiber... 10/20/2025
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A comparative fractographic analysis for the effect of polymeric nanofiber reinforcements on the tensile behavior of multi-layered epoxy nanocomposites
This study presents a comparative investigation into the effects of four different nanofibers—PA66, PStX, PAN, and PVB—on the mechanical performance and failure mechanisms of epoxy adhesive films. These nanofiber‐reinforced adhesive layers were manufactured via a dry‐reinforcement resin film infusion method and tested under uniaxial tensile loading. Mechanical results showed that PA66 and PStX nanofibers improved tensile strength by up to 25%, primarily by mitigating crack initiation at free edges and promoting effective fiber–matrix bonding. In contrast, PAN nanofibers induced micro‐cracks at the fiber–resin interface, amplifying crack coalescence and reducing strength by 25%. 03/01/2025