Transformable Peptide Nanoparticles Curb Bladder Tumors While Reducing Doxorubicin Toxicity In Mice in ssalimpour

Salimpour Website |Researchers developed a PLZ4-targeted, transformable peptide nanoparticle that carries the doxorubicin prodrug Leu-DOX and releases it in response to MMP9 in the tumor microenvironment. In cell studies and mouse models of bladder cancer, the platform increased tumor drug

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Transformable Peptide Nanoparticles Curb Bladder Tumors While Reducing Doxorubicin Toxicity In Mice

Transformable Peptide Nanoparticles Curb Bladder Tumors While Reducing Doxorubicin Toxicity In Mice

Researchers developed a PLZ4-targeted, transformable peptide nanoparticle that carries the doxorubicin prodrug Leu-DOX and releases it in response to MMP9 in the tumor microenvironment. In cell studies and mouse models of bladder cancer, the platform increased tumor drug retention and produced stronger antitumor effects with fewer measured signs of doxorubicin toxicity, supporting further preclinical investigation.