Design, Formulation, and Evaluation of Opthalmic Multilayer Nanofiber Insert for Management of Dry Eye Disease in ssalimpour

Salimpour Website |Due to changing lifestyles, millions of people worldwide experience dry eye disease (DED). The treatment for DED primarily involves the topical use of artificial tears and anti-inflammatory eye drops. Frequent administration of conventional eye drops leads to reduced patient

ResearchGate

Design, Formulation, and Evaluation of Opthalmic Multilayer Nanofiber Insert for Management of Dry Eye Disease

Design, Formulation, and Evaluation of Opthalmic Multilayer Nanofiber Insert for Management of Dry Eye Disease

Due to changing lifestyles, millions of people worldwide experience dry eye disease (DED). The treatment for DED primarily involves the topical use of artificial tears and anti-inflammatory eye drops. Frequent administration of conventional eye drops leads to reduced patient adherence. This study aims to improve the convenience and reduce the dosing frequency, by designing dexamethasone sodium phosphate (DSP)-loaded multilayer nanofiber inserts (MLNI) for managing DED. The drug-loaded electrospun nanofibers were sandwiched between two blank nanofiber scaffolds. The outer nanofiber scaffolds will aid mucoadhesion and lubricate the cornea to reduce the dryness.