ResearchGate |
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Design, Formulation, and Evaluation of Opthalmic Multilayer Nanofiber Insert for Management of Dry Eye Disease |
Due to changing lifestyles, millions of people worldwide experience dry eye disease (DED). The treatment for DED primarily involves the topical use of artificial tears and anti-inflammatory eye drops. Frequent administration of conventional eye drops leads to reduced patient adherence. This study aims to improve the convenience and reduce the dosing frequency, by designing dexamethasone sodium phosphate (DSP)-loaded multilayer nanofiber inserts (MLNI) for managing DED. The drug-loaded electrospun nanofibers were sandwiched between two blank nanofiber scaffolds. The outer nanofiber scaffolds will aid mucoadhesion and lubricate the cornea to reduce the dryness. |
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2024-12-01 Read more about this article in source |
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A comparative fractographic analysis for the effect of polymeric nanofiber reinforcements on the tensile behavior of multi-layered epoxy nanocomposites
This study presents a comparative investigation into the effects of four different nanofibers—PA66, PStX, PAN, and PVB—on the mechanical performance and failure mechanisms of epoxy adhesive films. These nanofiber‐reinforced adhesive layers were manufactured via a dry‐reinforcement resin film infusion method and tested under uniaxial tensile loading. Mechanical results showed that PA66 and PStX nanofibers improved tensile strength by up to 25%, primarily by mitigating crack initiation at free edges and promoting effective fiber–matrix bonding. In contrast, PAN nanofibers induced micro‐cracks at the fiber–resin interface, amplifying crack coalescence and reducing strength by 25%. 03/01/2025