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Topic: Nanofiber Applications in Wound Healing and Skin Regeneration Date |
Nanofiber technology is emerging as a transformative approach in the fields of wound healing and dermal regeneration, providing innovative solutions that significantly enhance traditional treatment methods. Nanofibers, with their high surface area-to-volume ratio, intrinsic porosity, and mechanical robustness, closely mimic the extracellular matrix, thereby promoting cell adhesion, proliferation, and migration essential for effective tissue repair. This abstract delves into the multifaceted applications of nanofibers in wound care, highlighting their capacity to deliver therapeutic agents in a controlled manner, retain moisture, and provide antimicrobial properties, |
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2024-07-01 Read more about this article in source |
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Evaluation of Moringa oleifera Incorporated With Zinc Oxide Nanoparticles/Poly(Vinyl) Alcohol Nanofibers as Antibacterial Material
Antibacterial materials are increasingly significant, particularly for biomaterials and food packaging applications. Materials with good elasticity and antibacterial properties are crucial in this line of work. This study focused on the investigation of nanofiber properties in elasticity and antibacterial by combining Moringa oleifera (MO) zinc oxide nanoparticles (ZnO NPs) with polyvinyl alcohol (PVA) nanofiber. The PVA/MO/ZnO nanofiber is fabricated using the electrospinning method. The morphology of PVA/MO/ZnO nanofiber shows smooth and uniform fibers with 292 nm in diameter size. The EDX mapping also demonstrates the successful loading of ZnO NPs into fibers, 12/01/2024 -
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Fabrication and acoustic absorption properties of electrospun polyacrylonitrile nanofiber membranes
As noise pollution becomes an increasingly important environmental issue, the development of advanced materials for noise reduction has attracted widespread attention. Nanofiber membranes, due to their high specific surface area, low density, and unique porous structure, exhibit excellent sound absorption performance, especially in the mid-to-low frequency range. In this study, polyacrylonitrile (PAN) nanofiber membranes with different mass fractions were fabricated using the electrospinning technique to investigate their sound absorption properties. The acoustic characteristics of the nanofiber membranes were analyzed through experiments and COMSOL simulation. 12/01/2024 -
Due to the direct long-term contact with living tissue, the biocompatibility of implants is particularly demanding. In this context, biointegration of implants highly depends on cell colonialization on the surface or in the gap between implant and tissue, as well as cell ingrowth in porous implant structures. Fibrous material is predestined based on two variable parameters, fiber thickness and pore size. Various applications in implant coating, stenting, wound treatment, bone surgery, or cardiovascular field are possible. Coating with cell-friendly material can significantly improve the biocompatibility of the underlying material. In this study, the biocompatibility of medical device 12/01/2024
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Purpose As a result of referee evaluation, the subject scope of the article has been expanded. Previously, only polycaprolactone (PCL) loaded with peppermint extract had been studied. As a result of peer review, nanostructure production was made with peppermint-loaded polylactic acid (PLA). Literature information about PLA polymer has been added to the Introduction section. Additionally, to analyze the presence of peppermint extract in Fourier transform infrared (FTIR) measurements, a comparison was made with 100% PCL, 100% PLA and 100% peppermint extract. In order to observe the effect of polymer type, evaluations were made between the produced peppermint-loaded nanostructures containing 12/01/2024
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Investigating the influence of polyacrylonitrile nanofiber thickness on particulate matter filtration performance from cigarette smoke
This study successfully fabricated polyacrylonitrile (PAN) nanofiber in various thicknesses as particulate matter (PM) filtration membranes using the electrospinning method. The PM source used was derived from cigarette smoke. Scanning electron microscopy (SEM) images and Fourier-transform infrared (FTIR) spectra are provided in the manuscript to observe the morphology and chemical composition of the fabricated nanofiber membrane. The thickness of the nanofiber was controlled based on the volume of the polymer solution, which was 4 mL, 6 mL, and 8 mL, and had a thickness of (52 ± 2) µm, (176 ± 27) µm, and (479 ± 38) µm, respectively (denoted as NF-4, NF-6, and NF-8 membranes). 12/01/2024 -
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A Multifunctional Photothermal Electrospun PLGA/MoS2@Pd Nanofiber Membrane for Diabetic Wound Healing
Injury caused by excess reactive oxygen species (ROS) may lead to susceptibility to bacterial infection and sustained inflammatory response, which are the major factors impeding diabetic wound healing. By utilizing optimal anti-inflammatory, antioxidant, and antibacterial biomaterials for multifunctional wound dressings is critical in clinical applications. In this study, a novel electrospun PLGA/MoS2@Pd nanofiber membrane was synthesized by encapsulating antioxidant and near-infrared (NIR) responsive MOS2@Pd nanozymes in PLGA nanofibers to form a multifunctional dressing for diabetic wound repair. With excellent biocompatibility and hemostatic ability, this novel PLGA/MoS2@Pd nanofiber 12/01/2024 -
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Insights into electrospun polymeric nanofiber mats: an innovative dressing for wound healing applications
Wound management is a complex clinical challenge that needs advanced materials and techniques for satisfactory results. Electrospun nanofiber mats have emerged as an innovative alternative for wound healing purposes due to their porous architecture, greater surface area, ease of water absorption, mimicry of the extracellular matrix of natural tissues and tunable mechanical properties. This paper sheds light on recent advances in the fabrication techniques, properties, structural features and application of electrospun polymeric nanofiber mats for wound healing purposes emphasizing the importance of polymer selection and processing parameters in tailoring their physicochemical properties. 12/01/2024 -
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Design, Formulation, and Evaluation of Opthalmic Multilayer Nanofiber Insert for Management of Dry Eye Disease
Due to changing lifestyles, millions of people worldwide experience dry eye disease (DED). The treatment for DED primarily involves the topical use of artificial tears and anti-inflammatory eye drops. Frequent administration of conventional eye drops leads to reduced patient adherence. This study aims to improve the convenience and reduce the dosing frequency, by designing dexamethasone sodium phosphate (DSP)-loaded multilayer nanofiber inserts (MLNI) for managing DED. The drug-loaded electrospun nanofibers were sandwiched between two blank nanofiber scaffolds. The outer nanofiber scaffolds will aid mucoadhesion and lubricate the cornea to reduce the dryness. 12/01/2024 -
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Improving interlaminar fracture toughness and compression after impact strength of carbon fiber reinforced epoxy composites by interleaving electrospinning polyethersulfone nanofiber
The effect of membrane thickness of electrospinning polyethersulfone (PES) nanofiber membranes on interlayer toughness and impact resistance of carbon fiber reinforced epoxy resin (CF/EP) composites are researched. Intercalation composites with different nanofiber membrane thicknesses, ranging from 10 to 50 μm, are tested at mode I and mode II interlaminar fracture toughness. The impact resistance of nanofiber membranes with different thicknesses is evaluated by the compression after impact (CAI) strength test. Moreover, nanofiber toughening contributions are investigated using the crack path and surface analysis. Results indicate that PES nanofibers increase the toughness of interlayer 12/01/2024 -
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Comparison of nanofiber production techniques and production of PAN nanofiber using air-assisted electrospinning
ELECTROSPINNING This paper explores alternative techniques for increasing nanofiber production and experimental studies to optimise the process parameters for air filtration applications. anotechnology, a rapidly evolving field, has permeated diverse industries, including tissue engineering , drug delivery, protective clothing , air filtration, energy storage, composites , and separation membranes 1. Its wide range of applications has sparked global research interest. One notable area is air filtration, where nanotech-nology brought about significant improvements concerning the efficacy and reductions in adverse events, resulting from the various outstanding properties of nanomaterials such 11/01/2024 -
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Nanofiber/Nanoparticle Electrodes for Ultra‐low Platinum Fuel Cells via Simultaneous Foam Electrospinning and Electrospraying
In this study, we developed a new technique, simultaneous foam electrospinning and electrospraying (FE/E), that produces nanofiber/nanoparticle electrodes at higher production rates compared to needle‐based electrospinning and electrospraying (E/E). Herein, the nanofiber amount was precisely controlled by applying various voltages on the foam electrospinning process at a fixed platinum (Pt) loading, which enables an exclusive investigation into the impact of ionomer nanofiber on fuel cell performance at ultra‐low Pt loadings for proton exchange membrane fuel cells. The results show that fuel cell performance is strongly dependent on ionomer nanofiber content. At 0. 11/01/2024 -
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Electrospun Micro/Nanofiber-Based Electrocatalysts for Hydrogen Evolution Reaction: A Review
Hydrogen is regarded as an ideal energy carrier to cope with the energy crisis and environmental problems due to its high energy density, cleanliness, and renewability. Although there are several primary methods of industrial hydrogen production, hydrogen evolution reaction (HER) is an efficient, eco-friendly, and sustainably green method for the preparation of hydrogen which has attracted considerable attention. However, this technique is characterized by slow reaction kinetics and high energy potential owing to lack of electrocatalysts with cost-effective and high performance which impedes its scale-up. To address this issue, various studies have focused on electrospun 11/01/2024 -
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Influence of the PAN:PEO Ratio on the Morphology of Needleless Electrospun Nanofiber Mats Before and After Carbonization
Nanofiber mats with a high surface-to-volume ratio can be prepared by electrospin-ning. The Porosity is sometimes reported to be tunable by blending different materials, e.g., water-soluble poly(ethylene oxide) (PEO) with not water-soluble poly(acrylonitrile) (PAN). Here, nanofiber mats were electrospun from different PAN:PEO ratios, using a wire-based electrospinning machine "Nanospider Lab". Investigations of the as-spun nanofiber mats as well as of membranes after washing off the water-soluble PEO by scanning electron microscopy (SEM) revealed severe differences in the nanofiber mat morphologies, such as varying fiber diameters and especially non-fibrous areas in the carbonized nanofiber 11/01/2024 -
In electrospinning, nanofibers are frequently produced in nonwoven web form. Their poor mechanical properties (below 100 MPa) and difficulty in tailoring the fibrous structure have restricted their applications. However, advanced materials must be highly resistant to both deformation and fracture. By combining electrospinning technology with stretching, we have overcome this disadvantage and demonstrated a polyacrylonitrile nanofiber yarn with a tensile strength of 743 ± 20 MPa. The nearly perfect uniaxial orientation of the fibrils under the stretching process is crucial for the remarkable mechanical properties of the yarn. Additionally, the nanofiber yarn was functionalized by a 11/01/2024
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Therapeutic effects of acyclovir and acyclovir-clobetasol nanofibers vs. cream formulation for recurrent herpes labialis
Objectives This study aims to compare the therapeutic effects of acyclovir nanofiber and acyclovir-clobetasol nanofiber formulations with their non-nano formulations (cream formulation) on recurrent labial herpes. Materials and methods Eighty patients with labial herpes lesions were divided into four groups, each receiving one of the following treatments: acyclovir-clobetasol nano patch, acyclovir-clobetasol cream, acyclovir nano patch, or acyclovir cream. Pain levels and recovery times were assessed. The Wilcoxon test compared pain levels, while the log-rank test compared healing and scabbing times. Results Acyclovir-clobetasol nanofiber and cream, along with acyclovir nanofiber, 11/01/2024